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Re:Chemistry Nobel: Computational protein design and protein... by flobosg on Wednesday October 09, 2024 @02:25PM (#41791069)
> Rosetta used sequence homology

Rosetta used remote sequence homology to generate the MSAs and find template fragments, which at the time was innovative. A similar strategy is employed for AlphaFold’s MSAs containing the evolutionary couplings.

Re:Chemistry Nobel: Computational protein design and protein... by timr on Thursday October 10, 2024 @02:33AM (#41796166)
Yep. That's what I'm saying.