Re:Chemistry Nobel: Computational protein design and protein...
by pama on Wednesday October 09, 2024 @01:12PM
(#41790237)
Agreed. There are too many different directions of impact to point out explicitly, so I'll give a short vignette on one of the most immediate impacts, which was the use in protein crystallography. Many aspiring crystallographers correctly reorganized their careers following AlphaFold2, and everyone else started using it for molecular replacement as a way to solve the phase problem in crystallography; the models from AF2 allowed people to resolve new crystal structures from data measured years prior to the AF2 release.
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Re:Chemistry Nobel: Computational protein design and protein...
by flobosg on Wednesday October 09, 2024 @01:17PM
(#41790285)
Same with Rosetta, and even Foldit[1]! – https://www.nature.com/articles/nsmb.2119