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Re:Chemistry Nobel: Computational protein design and protein... by DevX101 on Wednesday October 09, 2024 @06:41AM (#41786346)
Here's a direct quote from the Alphafold paper:

"These authors contributed equally: John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Demis Hassabis"

Re:Chemistry Nobel: Computational protein design and protein... by t_mann on Wednesday October 09, 2024 @06:56AM (#41786443)
Here's 8 densely printed pages of contributors to a discovery that lead to a Nobel prize:

https://arxiv.org/pdf/1207.7214#page=26

Guess how many of them were included in the prize. It's a shame that the Nobel committee shies away from awarding it to institutions, but the AlphaFold prize doesn't even make the top 10 in a list of most controversial omissions from a Nobel prize. It's a simple case of lab director gets the most credit.

Re:Chemistry Nobel: Computational protein design and protein... by throwaway48476 on Wednesday October 09, 2024 @07:40AM (#41786774)
Perhaps it's time the prize goes to the discovery itself instead of a person.
Re:Chemistry Nobel: Computational protein design and protein... by BurningFrog on Wednesday October 09, 2024 @11:25AM (#41788883)
How do you give $1M to a discovery?
Re:Chemistry Nobel: Computational protein design and protein... by throwaway48476 on Wednesday October 09, 2024 @05:14PM (#41792712)
$1M ain't what it used to be.
Re:Chemistry Nobel: Computational protein design and protein... by ascorbic on Wednesday October 09, 2024 @08:27AM (#41787145)
It's not a case of shying away from it: the rules of the prize don't allow it.
Re:Chemistry Nobel: Computational protein design and protein... by myworkinisgood on Wednesday October 09, 2024 @08:53AM (#41787405)
rules of the prize can be changed.
Re:Chemistry Nobel: Computational protein design and protein... by afthonos on Wednesday October 09, 2024 @09:53AM (#41788013)
Can they? I mean, in the sense that you can yolo anything, sure, but the prizes were designed in a time when it was (more) reasonable to award them to individuals, and they are defined in a will. There may not be a mechanism for updating the standards.
Re:Chemistry Nobel: Computational protein design and protein... by hyperbrainer on Wednesday October 09, 2024 @11:21AM (#41788844)
Yes, they can. In 1901, science was not nearly as collaborative as it is today. Especially considering the need for a Nobel Prize to be experimental and the fact that most major labs today _need_ dozens of people.
Re:Chemistry Nobel: Computational protein design and protein... by achierius on Wednesday October 09, 2024 @11:49AM (#41789240)
He asked _can_ not _should_: what is the legal mechanism for doing so? Personally I don't doubt there is one but I don't think you know it off the top of your head, so I don't see it as fair to disparage OP for not knowing either.
Re:Chemistry Nobel: Computational protein design and protein... by hyperbrainer on Wednesday October 09, 2024 @12:22PM (#41789669)
Well, it seems like amendments have been made before. [0] > Before the board ... votes on a proposal to amend the statutes ... with the first paragraph, the prize-awarding bodies shall examine the proposal.

https://www.nobelprize.org/organization/special-regulations-...

Re:Chemistry Nobel: Computational protein design and protein... by afthonos on Wednesday October 09, 2024 @11:49AM (#41789236)
That…has nothing to do with my question. It was a procedural and legal question, not an abstract moral one.
Re:Chemistry Nobel: Computational protein design and protein... by hyperbrainer on Wednesday October 09, 2024 @12:22PM (#41789671)
Well, it seems like amendments have been made before. [0] > Before the board ... votes on a proposal to amend the statutes ... with the first paragraph, the prize-awarding bodies shall examine the proposal.

https://www.nobelprize.org/organization/special-regulations-...

Re:Chemistry Nobel: Computational protein design and protein... by DevX101 on Wednesday October 09, 2024 @07:10AM (#41786539)
The nature of scientific work has changed significantly since 1895, when the Nobel Prizes were established. 100 years ago, lots of scientific work really were driven forward largely by a singular person. That's rarely true today for groundbreaking research. I don't know if this means the Nobel needs to change or we need a another prize that reflects the collaborative work of modern science.
Re:Chemistry Nobel: Computational protein design and protein... by aleph_minus_one on Wednesday October 09, 2024 @09:17AM (#41787657)
> The nature of scientific work has changed significantly since 1895, when the Nobel Prizes were established. 100 years ago, lots of scientific work really were driven forward largely by a singular person. That's rarely true today for groundbreaking research.

The question is: is this a necessity for doing good science today, or rather an artifact of how important research is organized today (i.e. an artifact of the bureacratic and organizational structure that you have to "accept"/"tolerate" if you want to do want to have a career in science)?

Re:Chemistry Nobel: Computational protein design and protein... by DevX101 on Wednesday October 09, 2024 @09:47AM (#41787942)
So I did a mini research project on Claude to answer your question. From 1900-1930, 87% of Nobel Prizes in Physics, Chemistry and Physiology/Medicine were awarded to individual contributions, 13% were awarded to collaborative contributions.

This ratio has flipped in the past 30 years, from 1994-2023, where 17% prizes were individual, 83% collaborative.

So I'd say yes, collaborative work is increasingly a requirement to do groundbreaking research today. The organizational structures and funding are a part of the reason as you mention. But it's also that modern scientific problems are more complex. I used to have a professor that used to say about biology "the easy problems have been solved". While I think that's dismissive to some of the ingenious experiments done in the past, there's some truth to it.

Re:Chemistry Nobel: Computational protein design and protein... by afthonos on Wednesday October 09, 2024 @09:56AM (#41788044)
This begs the question. If all science is now structured as big research teams, we'd expect the breakthroughs to come from such teams. That doesn’t necessarily imply that teams are needed.
Re:Chemistry Nobel: Computational protein design and protein... by aleph_minus_one on Wednesday October 09, 2024 @04:00PM (#41792007)
Your argument is exactly a central part of the point that I raised.
Re:Chemistry Nobel: Computational protein design and protein... by stenl on Wednesday October 09, 2024 @07:01AM (#41786474)
And further down: ” Contributions

J.J. and D.H. led the research. J.J., R.E., A. Pritzel, M.F., O.R., R.B., A. Potapenko, S.A.A.K., B.R.-P., J.A., M.P., T. Berghammer and O.V. developed the neural network architecture and training. T.G., A.Ž., K.T., R.B., A.B., R.E., A.J.B., A.C., S.N., R.J., D.R., M.Z. and S.B. developed the data, analytics and inference systems. D.H., K.K., P.K., C.M. and E.C. managed the research. T.G. led the technical platform. P.K., A.W.S., K.K., O.V., D.S., S.P. and T. Back contributed technical advice and ideas. M.S. created the BFD genomics database and provided technical assistance on HHBlits. D.H., R.E., A.W.S. and K.K. conceived the AlphaFold project. J.J., R.E. and A.W.S. conceived the end-to-end approach. J.J., A. Pritzel, O.R., A. Potapenko, R.E., M.F., T.G., K.T., C.M. and D.H. wrote the paper.”

Re:Chemistry Nobel: Computational protein design and protein... by stephencanon on Wednesday October 09, 2024 @07:15AM (#41786576)
> J.J. and D.H. led the research

Hey, I wonder who these mysterious "J.J." and "D.H." might be?

Re:Chemistry Nobel: Computational protein design and protein... by onursurme on Wednesday October 09, 2024 @07:11AM (#41786543)
These people aren't in the "These authors contributed equally" list.
Re:Chemistry Nobel: Computational protein design and protein... by seydor on Wednesday October 09, 2024 @06:51AM (#41786406)
They didnt give the award to the paper
Re:Chemistry Nobel: Computational protein design and protein... by onursurme on Wednesday October 09, 2024 @06:56AM (#41786445)
The paper represents the work which lead to the prize.

if A=B and A=C, then A=C

Re:Chemistry Nobel: Computational protein design and protein... by SkiFire13 on Wednesday October 09, 2024 @07:01AM (#41786480)
> if A=B and A=C, then A=C

Technically true, but you might still want to double check your logic.

Re:Chemistry Nobel: Computational protein design and protein... by fastball on Wednesday October 09, 2024 @07:10AM (#41786536)
Not all of the work. For example, it doesn't account for the fact that Demis Hassabis, as head of DeepMind, undoubtedly recruited many of the co-authors to participate in this effort, which is worth something when it comes to the final output.
Re:Chemistry Nobel: Computational protein design and protein... by onursurme on Wednesday October 09, 2024 @07:50AM (#41786842)
To recruit isn't scientific work.
Re:Chemistry Nobel: Computational protein design and protein... by fastball on Wednesday October 09, 2024 @03:06PM (#41791504)
I didn't realize the Nobel specified that the only work which mattered was that of the "scientific" variety.
Re:Chemistry Nobel: Computational protein design and protein... by warkdarrior on Wednesday October 09, 2024 @10:50AM (#41788509)
What will the paper do with the prize money?
Re:Chemistry Nobel: Computational protein design and protein... by Rochus on Wednesday October 09, 2024 @08:28AM (#41787151)
At least they could have read it before awarding the price.