Re:Chai-1 Defeats AlphaFold 3
by ashvardanian on Tuesday September 10, 2024 @11:16PM
(#41507728)
There is a pretty noticeable improvement for antibody-antigen interactions - looks like double-digit percents. Check out figure 4 here: https://chaiassets.com/chai-1/paper/technical_report_v1.pdf
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Figure 4 is comparing the model with itself, unless I'm misunderstanding it. The takeaway seems to be the model performs better if you give it extra "constraints", i.e. extra info already known about the protein.
The table with a comparison to alpha fold gives a less than one percentage point improvement.