I keep SELinux enabled at all times, but it does break quite often. For the sake of sticking to Fedora, wg-quick (wireguard) does not work out of the box.

On OpenSUSE/MicroOS who is employing SELinux boot takes about 5 minutes on every kernel change, because of home-relabel. I hear you, that they probably do it wrong, but that's what you get with SELinux. Not enough to push me to disable SELinux, but maybe to avoid SELinux distributions in the future.