I'd expect that long term the brine would do bad things near the places it is released but would not have any noticeable long term consequences much farther away as long as we don't discharge it somewhere where it destroys something local that turns out to be a dependency of something far away.

That's because almost all the water that is taken out of the ocean will make its way back to the ocean. We just borrow it for a while.

If all the water used by humans were taken from the ocean, we'd take about 1/300000th of the ocean's water per year. Most of that will be back in the ocean within 200 years. That puts the cap on the amount of water that would be missing from the ocean of 1/1500th of its volume, which means that the steady state increase in salt concentration would be less than 0.1%, which is much less than the natural variation in ocean salt levels.