Packing your basic web site with 50,000+ SLOC worth of run time dependencies is quite a different story. When you use a framework like react, or vue, or svelte, you're bringing in a massive dependency tree, and you're also changing the semantics of the application code from web standard code to framework specific code. Instead of being an expert on the standards, you have to become an expert in the framework. There are compromises being made either way.

I think that one important thing missing from this project is a templating engine of some kind. Questionable addition though, since you're then going to stop writing HTML and start writing whatever template language. And it's a greased path toward going with a framework.