I think modern Intel/AMD have same amount of dTLB entries for all page sizes. For example a modern CPU with 3k TLB entries one can access at max: - 12MB with 4k page size - 6GB with 2M page size - 3TB with 1G page size

If the working set per core is bigger than above numbers you get 10-20% slower memory accesses due to TLB miss penalty.