Does anybody have experience using this in a real-world setting?

I can understand the desire to never, ever have to deal with Zookeeper again, but does the ergonomics promise of sequin hold up?

I've done similar things with PostgreSQL and MS-SQL, and it's worked fine for relatively active queues/events/streams, etc. In particular email queues, where the rendered body is captured in the DB, so it can be displayed as-is in an email link itself, or for an sms message link.

It will really depend on your needs... do you have tens, hundreds... or millions of messages a second you need to process? Is this bursty or constant?