I have the twin Dell 24's with an MBP -- here's an image how I have it setup: http://briandear.tumblr.com/post/24403674220/my-development-...

Maybe not the "best" way, but perfect for my workflow (I deal with mobile web development so I need a bunch of small browser windows open simultaneously to test on the multitude of mobile user agents.) I usually have specs, chrome, campfire, email on the left, code in the center and my development browser windows on the right.