Re:Molecule restores cognition, memory in Alzheimer's diseas...
by BenFranklin100 on Thursday August 08, 2024 @10:15PM
(#41198280)
To add to your point, over the least decade animal models are increasingly being seen as models of specific mechanisms, rather than as complete models of a human disease.
To relate this back to the AD field, researchers have developed mouse models to better understand the specific steps in the development of a form of angiopathy seen in humans, cerebral amyloid angiopathy; that is, amyloid plaques that develop on blood vessels. This is being done in the hope that these models will elucidate the basic biology of CAA, and thus help researchers make more informed no/go decisions about CAA therapies in humans.
Re:Molecule restores cognition, memory in Alzheimer's diseas...
by jdoe2020 on Sunday August 11, 2024 @12:06PM
(#41217151)
This is really good point. People underestimate he degree failed trials have value in understanding the basic science behind diseases, especially mechanistically complex ones.
To relate this back to the AD field, researchers have developed mouse models to better understand the specific steps in the development of a form of angiopathy seen in humans, cerebral amyloid angiopathy; that is, amyloid plaques that develop on blood vessels. This is being done in the hope that these models will elucidate the basic biology of CAA, and thus help researchers make more informed no/go decisions about CAA therapies in humans.