So long as the policy is perpetuated by people who are elected by those who still sheltered from the worst of it, I wouldn't expect any change.
Particularly not now that there's a robust military-incarceration-industrial lobby with a strong incentive to maintain the status quo and no limitation on their ability to make 'campaign contributions'.
Having a gigantic drug war going on right across the US border in Mexico is a crazy thing to begin with. Add to that it's about owning territory to import drugs into the US, to feed a large demand.
Plus the cartels make bales of money on marijuana sales, when it could easily be a huge cash crop for so many US counties. Job creation blah blah blah.
I'd support legalization and taxation of marijuana, it seems like the honest thing to do since it's everywhere anyway and doesn't seem to destroy people's lives like crack and meth.
Drugs don't destroy lives, addiction does. Prohibition drives addicts underground. This makes the problem harder to solve, not easier.
The legal status of tobacco and alcohol are proof-positive that biology isn't the metric that's used. It's politics and big business, pure and simple.
50,000 people dead? - check. Billions in profit? - check. Narco-states on the US border? - check. Criminals walk out of prison? - check. Gigantic crack & methaphetamine problem within the US? - check.