My claim is that the guarantees that TS provides aren't strong enough to help a compiler produce stronger optimizations. Types don't just magically make code faster - there's specific reasons why they can make code faster, and TypeScript's type system wasn't designed around those reasons.

A compiler might be able to wring some things out of it (I'm skeptical about obviouslynotme's suggestions in a cousin comment, but they seem insistent) or suppress some checks if you're happy with a segfault when someone did a cast...but it's just not a type system like, say, C's, which is more rigid and thus gives the compiler more to work with.