That essentially means that you can't use any services that happen to be hosted behind Cloudflare, like OpenAI/ChatGPT, GitLab, Hubspot and Shopify. And anyone on WARP and about half of iCloud Private Relay requests won't make it to your services.

I suppose it strongly depends on your organisation, but I'm not seeing how this would be a realistic option unless you're very powerful or have a lot of cash to burn on non-core business processes.