Some people like myself are very sensitive to some some vocal/audio oddities, while others seem insensitive to it.

The issue is for those sensitive, it literally creates the feeling sick and/or needing to escape or fight the situation (rage) despite rationally knowing there’s nothing wrong. See: misophonia

While sometimes the cause is unavoidable, reducing the avoidable ones is worthwhile, though I would agree that getting paranoid about it isn’t needed.

For those that encounter this in video/audio, a useful trick I’ve found is watching at a higher playback speed, which seems to mask many of the things that would drive me mad.

Definitely don't stress, but it is certainly some low hanging fruit. The quality of the animations is far beyond the quality of the audio. There's no reason the creator needs to care. But given the care and attention put into the appearance of the animation, they just might.