Up to a couple of years ago, before permanently moving to AMD GPUs, I couldn't even boot Ubuntu with an Nvida GPU. This was because Ubuntu booted by default with Nouveau, which didn't support a few/several series (I had at least two different series).

The cards worked fine with binary drivers once the system was installed, but AFAIR, I had to integrate the binary driver packages in the Ubuntu ISO in order to boot.

I presume that now, the situation is much better, but necessiting binary drivers can be a problem in itself.