PyInstaller + bundling the dlls and binaries works well for me

One annoying problem that I encountered with that approach was different binaries having different version conflicts on different platforms. Not unsolvable, but definitely unsolvable without a whole lot of irritation, and a huge PITA to maintain. It definitely makes it possible though, which is a whole lot better than nothing.

I haven't encountered any silver ammunition for that particular gun. I haven't worked on a big python project in a while, so I'm not sure if rye would do the trick.