>niche use cases (such as WebRTC, WebUSB,WebGL, WebAudio and so on and so forth)

WebUSB is a lot more common than one might think, but I mostly see it used in music gear. Companies like Novation use WebUSB to facilitate firmware upgrades, backups, patch management, etc with their synthesizers and workstations.

Its pretty much a necessity for me at this point so that I can remain OS agnostic and still manage my gear.