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Re:The brain makes a lot of waste. Now scientists think they... by pedalpete on Saturday June 29, 2024 @08:14PM (#40834239)
Yes, reduced muscle tone is absolutely established, now I think I know what you're saying. We're often letting the researchers guide the areas they are most interested in. Lot's of interest in Alzheimer's, Parkinson's, and depression. We're interested in looking at insulin response and other metabolic factors.
Re:The brain makes a lot of waste. Now scientists think they... by spacetimeuser5 on Sunday June 30, 2024 @04:53PM (#40840283)
Yea, lot's of interest in making the subjects better taxpayers rather than how the brain/mind actually work.

Insulin response and other metabolic factors seem currently not measurable non-invasively, like EEG. That's why I was focusing on muscle tone as an easily available parameter which can be measured continuously and non-invasively, in line with EEG. Temperature is another similar parameter and I've seen a couple of studies showing reduced frontal lobes' temperature promotes sleep.

It can seem tricky to reduce it without pharma or techniques performed while awake, but I've collected a corpus of research which may allow to emulate the action of e.g. GABA without adding the actual GABA (which is thought to induce muscle paralysis in sleep), thus non-invasively promoting the reduction of skeletal muscle tone.