This is a fun thing to think about, but commercialization of drugs is antagonistic towards the drugs working around the drug enforcement agencies that technically provide legal highs.

Cannabis is the closest thing that’s combining the two. MDMA is possible, but I can imagine can be synthesized to remove the euphoria once there has been more testing. Mushrooms, LSD, and Ketamine all show their maximum effectuation at lower doses would be taken recreationally.