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A comment on Gilead Shot Prevents All HIV Cases in Trial of African Women. Parent comment

Re:Gilead Shot Prevents All HIV Cases in Trial of African Women by duskwuff on Thursday June 20, 2024 @05:01PM (#40743319)
Twice a year, but yes. That's a huge benefit -- not only is it easier for patients to stay on the treatment, but it's likely to be a lot cheaper as well.
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Re:Gilead Shot Prevents All HIV Cases in Trial of African Women by smeej on Thursday June 20, 2024 @10:16PM (#40745533)
I wonder how much variation there might be in terms of margin of error. Like, how close do they have to get to keeping people on a rigid 6-month schedule? Would 7 be fine? For what percentage of people? I'm assuming they have reason to believe once a year isn't enough, so that's an upper bound, but what's the lower one?
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Re:Gilead Shot Prevents All HIV Cases in Trial of African Women by adgjlsfhk1 on Friday June 21, 2024 @12:10AM (#40746066)
the short answer is no one knows (yet). if/once it gets approval, there likely would be a followup study on how much you can stretch the timing (possibly with dosage variation)
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Re:Gilead Shot Prevents All HIV Cases in Trial of African Women by duskwuff on Friday June 21, 2024 @12:42AM (#40746215)
> I wonder how much variation there might be in terms of margin of error.

Probably quite a bit. The trial used the same dose of lenacapavir as what's used for maintenance in HIV patients; it's quite possible that less is needed to prevent infection in a healthy patient. Unfortunately, there's really no safe/ethical way for them to test lower doses.

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Re:Gilead Shot Prevents All HIV Cases in Trial of African Women by oopsallmagic on Friday June 21, 2024 @12:28AM (#40746157)
It'll only be cheap once the patent expires. Until then, take those pills daily, y'all!
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