I suspect that A Deepness in the Sky would work best as animation, to emphasise the same plot point that had the spiders using familiar human nouns and only reveal the graphical truth at the same time in the story we find out the literary truth.

(I vaguely remember something like this happening with a monster's POV section in Schlock Mercenary, but that's a long web comic and I can't remember when in it's history to look for).