I was staying over at a friend's house and had some drinks (2 beers + 2 screwdrivers), and at the time was on SSRIs for about 4 months. My alcohol tolerance is fairly average and expected a light buzz. Instead I ended up wasted for the first time since college days. In my scenario, anti-depressants definitely amplified alcohol's effects.

Regardless of what you think, it's been clinically proven. That's why the drug's label has a warning about alcohol intake.

(http://www.medicalobserver.com.au/news/antidepressants-vs-ac...)

The current understanding is that the difference between SSRIs and active placebos is very small. When you take into account how many negative results have gone unpublished, it starts to look plausible that SSRIs have no psychiatric benefit beyond patients knowing 'I took a pill' and 'it has side effects'.