Everybody, in fact, takes innumerable social parameters into consideration when you say anything, especially with strangers.

For the sake of mass communication where you can’t really know your receiver, you have to do your best to just communicate whatever you need to (i.e. ‘a single approach’). Choosing to use a word that is ambiguous as to whether it is a slur is a bit unwise. I think it is probably unwise to do the same in personal interactions.