Published from Cell

https://www.cell.com/cell/abstract/S0092-8674(24)00398-2

But found some snippets from ScienceDirect:

https://www.sciencedirect.com/science/article/abs/pii/S00928...

>> Recent work with high-resolution imaging has revealed that viruses packaged together into vesicles are significantly more infectious than a single virus. Mimicking this structure, we developed a facile approach for substantially enhancing immunogenicity of tumor-encoding mRNA antigens in lipid particle (LP) delivery systems through formulation of multi-lamellar LP aggregates (LPA) that can simultaneously function as vaccines and as immunomodulating agents. We show that RNA-LPAs rapidly reprogram the TME in less than 24–48 h, allowing simultaneously activated T cells to exert their effector functions. This approach overcomes the first step necessary for successful cancer immunotherapy, tumor immunosuppression and systemic tolerance, allowing effector cells to compete in a hostile immunoregulatory host system to engender rapid and long-lasting immunologic responses across murine, canine, and human cancer.