Re:AlphaFold 3 predicts the structure and interactions of al...
by slashdave on Wednesday May 08, 2024 @05:44PM
(#40302999)
In terms of docking, you can call the conventional approaches "physically-based", however, they are rather poor physical models. Namely, they lack proper electrostatics, and, most importantly, basically ignore entropic contributions. There is no reason for concern.
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