In other abuses of SQLite, I wrote a tool [0] that exposes blobs in SQLite via an Amazon S3 API. It doesn't do expiry (but that would be easy enough to add if S3 does it).

We were using it to manage a millions of images for machine learning as many tools support S3 and the ability to add custom metadata to objects is useful (harder with files). It is one SQLite database per bucket but at the bucket level it is transactional.

0: https://github.com/seddonm1/s3ite