Can I ask - why the dislike for virtualenvwrapper? If you are saying that it can have occasional problems, I agree with you. But it makes the process so much simpler. The occasional problems I’ve had (had an issue once or twice deleting a venv) pales in comparison to the advantage I get in remembering a couple fast commands. Is there something better or am I relegated to “source what/directory/was/it/again/bin/activate?