My ereader of choice is the Asus EeeNote. Very hard to find, and I'm not sure it's even made anymore. I ordered one from Taiwan (thanks, Chrome's built-in translation!). It has a Wacom digitizer, so it needs a pen, but that also means it doesn't register finger presses (so you can rest your hand on the screen while you write). There are a couple buttons at the bottom so you can flip through pages or through the menu without needing the pen in your hand. It's not the best ereader out there, but it's the only one I know of built for handwriting and reading at the same time. Black and white screen with no backlight, which is reportedly the reason Asus never sold it in the US. They didn't think the market would be there.

It can also be used just for note-taking (wifi sync with Evernote), it has Firefox built-in for web browsing, has a camera and can take audio notes as well. Plays MP3s. I use it a lot for writing notes in class while recording the audio of the professor. When I get home, my notes are already on my PC. Sitting at home, I can plug it into my PC and use it like a 8" Wacom digitizer in Photoshop. Totally worth the $250 shipped from Taiwan.