HIV in cell culture can be completely eliminated using CRISPR-Cas gene editing [pdf]

Re:HIV in cell culture can be completely eliminated using CR... by nextaccountic on Tuesday March 19, 2024 @11:51PM (#39762712)

Does this means that in order to productionize this into a drug, one would need to basically engineer a biological virus?

[ Parent | on HN ]

Re:HIV in cell culture can be completely eliminated using CR... by jjtheblunt on Wednesday March 20, 2024 @01:52AM (#39763222)

https://en.wikipedia.org/wiki/Viral_vector

[ Parent | on HN ]

Re:HIV in cell culture can be completely eliminated using CR... by lucioperca on Wednesday March 20, 2024 @04:28AM (#39763961)

or mRNA

[ Parent | on HN ]

Re:HIV in cell culture can be completely eliminated using CR... by XorNot on Wednesday March 20, 2024 @06:37AM (#39764750)

CRISPR is pretty complicated - I'd say it's not clear whether mRNA of such length could stably produce enough enzyme in enough places. It's great when you need an antigen to be presented, but not so much when you need an entire restriction enzyme system.

[ Parent | on HN ]