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Re:HIV in cell culture can be completely eliminated using CR... by smt88 on Tuesday March 19, 2024 @11:43PM (#39762677)
How do Casgevy and Lyfgenia[1] avoid these dangerous mistakes? Is it something that can be generalized to other therapies, or does it need to be recreated for each "edit" that we want to turn into a therapy?

1. https://www.fda.gov/news-events/press-announcements/fda-appr...

Re:HIV in cell culture can be completely eliminated using CR... by ghkbrew on Wednesday March 20, 2024 @01:02AM (#39762994)
According to your link, both of those are applied to extracted stem cells which are then reintroduced. The ability to perform clonal expansion and DNA sequencing makes it possible that screening for off-target edits could be performed. Though I have no idea if it's actually done.