I've found that muscle memory helps a lot with meta-x and ctrl-g, but the save combo is never used. This is because I USA Mac and just use command-s for save nowadays. Muscle memory also helps with the other 2 macro keys, which are at the bottom left of the keyboard and fairly easy to hit with a pinky or ring finger. You're absolutely right, it's a reach and I'd prefer that the keys were positioned below the space bars.

I actually swapped out and moved the upper right keys such that I have a home and end key as well as page up/down and delete.

It's still my end game keyboard. It sounds and feels great!

(I'll check out the macro recorder too)