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Re:Scientists find genetic signature of Down syndrome in anc... by ajkjk on Wednesday February 28, 2024 @07:59PM (#39545433)
Apparently there have been a ton of advances in reading ancient DNA that make a lot more than 5000 years possible. There is a fairly readable summary of it all in the form of a somewhat-dry book, "Who We Are and How We Got Here", by David Reich.
Re:Scientists find genetic signature of Down syndrome in anc... by adolph on Wednesday February 28, 2024 @08:43PM (#39545710)
The Reich book is phenomenal. For something a little more accessible, there is the Nova episode: "Hunt for the Oldest DNA." It's a bit breathless if one has already encountered Reich, but gets the gist across.

https://www.youtube.com/watch?v=c2ppreiB1PQ