Probably - I knew somebody whose Rav 4 spontaneously started smoking from under the hood while she was driving on the freeway (this was probably 15 years ago), she pulled over and got out and within a few minutes the whole thing was completely up in flames.

Tyres are part of it, but then think of the oily residues that build up around the engine, the rubber hoses, plastic bumpers, etc. - not to mention the entire interior all being quite flammable.