Less resolute works in some cases and that was never at issue. The problem is, less resolute doesn't work for some things and when the sample size is a drop of blood, we're talking insanely small, as in impossible, sample size for some tests.

Low concentrations will NOT be reliably detected. That's part of why such a comparatively large sample is taken when you go for the traditional testing.

I'm not even going into the simple fact that once chems are introduced into the sample to generate reactions, the sample can't continue to be used.

Exactly how many times do you think we can split a single drop of blood?

Edit: good talk, even if we disagree. :)