Would like to second this question. I'm very interested in getting into this world, but it feels like there isn't a clear path (especially for someone self-taught like me). Bioinformatics feels pretty inaccessible without a computer science or biology degree, even with substantial R and Python experience.

I couldn't speak to careers, but my curiosity was enough for me to ask a biochemist to join his bioinformatics class despite lacking a great many prerequisites.

I was quite helpful to him and the other students (who mostly struggled with packaging: conda, pip, apt, etc). In turn, they were quite patient with my lack of biochemistry background. It was nice to get a taste without having to take what would've been 2.5 years worth of prerequisites.

There's a few camps in bioinformatics, from what I've seen.

1) The fellows writing papers - usually these guys have PhDs. Usually a science-focused PhD. 2) Analysts - often have a background in mathematics, biology, or big-data. Success here can lead to an onramp to camp 1. Much of your time here is spent in interactive programming environments, like Jupyter notebooks. 3) Programmers - writing novel or faster bioinformatic tools, often in low-level languages like C++ or Rust. Sometimes you can get a paper out of these, especially if you have a CS background. There's increasingly room for higher-level tools though here too, so it starts to overlap with 2. 4) Pipeline programmers - people gluing analysis workflows together out of the tools written in low-level languages, often with a liberal helping of Unix command-fu. Often sort of an ad-hoc role, containing people from diverse backgrounds, from biology to sysadmin. (This is my current role). 5) Biology/wetlab - people running experiments in the lab, and want to analyze their own work, especially for QC purposes. Wild-west ad-hoc development practices.

I think there’s a lot of gate keeping and having some formal degree is a pre-requisite. And be advised that pay isn’t great either.

But bioinformatics is an umbrella term. There’re so many different things people do. I started by identifying field I’m interested in (ageing and immunology) and backtracked from there.

Honestly the major pain point is that the grad student that wrote the package you need is no longer maintaining it because they’ve graduated. Also the code they wrote sucks, but whatever.

I’m wary of software engineers coming over the bioinformatics because they never have the domain expertise required to make meaningful contributions, and yet many think they know everything.

Yeah, I'm wary of being that guy too. My current approach is the slow one: first get a biochemistry degree.

I had an ok career in software engineering (Android/iOS -> backend -> engineering management) before getting MS in Bioinformatics and starting a PhD in Medicine.

For me, the pain points are often the same as in business. Biologists with no data analysis experience want something done without understanding constraints. Requirements are often not understood and there isn’t a good plan.

Some people do indeed suffer from code being slow and this can be solved with better tools. I works with large datasets in single-cell genomics (over a million cells) and the model takes ~12 hrs to train on an entry-level GPU. So, most o my time is spent at trying to understand the results.