You didn’t ask me, but I’ll chime in here. I run 6 monitors — four landscape in a 2x2 config and a portrait on either side. I use the bottom right landscape for most web browsing, email, and sharing my screen. When I’m sharing I do those things on bottom left landscape. Top monitors are for reference type info as they’re too high to stare at for long periods. Top left is downloads folder, CPU/RAM/etc monitors, sticky note, and to-do list. Top right is calendar and security cameras. Right portrait is slack (portrait is great for this, lots of history without scrolling). Left portrait is windows explorer. It’s super fast to just move the mouse and turn my head to what I need without switching windows as much.
My setup is similar to your multi-monitor arrangement, except instead of moving my head I switch between respective window sets in Stage Manager (macOS).
One downside is that my neck does not exercise much because I do not look in different directions while working. Another downside is that at certain times context can involve multiple window sets, but that is rare, and it comes with an upside: it is easier to focus on one task without windows on other monitors distracting me.
Well, that only leaves one question: Why so few monitors?
More seriously, I'd be really interested to hear your system for arranging things across all that real estate and how you use it optimally.
I used to have 2.5 monitors (two widescreens + a laptop off to the side) --- but after several moves, the inexorable passage of time, and my growing laziness, I now just spend my workdays hunched over a single laptop.