That's the problem.

It's not ethical to perform experiments on human subjects without their explicit consent.

That's why the Institutional Review Board was created:

https://en.wikipedia.org/wiki/Institutional_review_board

You can't just perform experiments on large groups of people to see what will happen.

So in short, neither you nor I know what human nature is, and thus setting up criteria for social organization on whether it aligns with "human nature" is impossible, and a foolish goal.