https://nanoporetech.com/products/sequence/minion
Sequencing DNA with nanopores: Troubles and biases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486125/
Based on what I'm seeing from 23andMe's website they only do genotyping, not sequencing.
https://customercare.23andme.com/hc/en-us/articles/227968028...
"23andMe uses genotyping, not sequencing, to analyze your DNA. Sequencing technology has not yet progressed to the point where it is feasible to sequence an entire person’s genome quickly and cheaply enough to keep costs down for consumers. It took the Human Genome Project, a consortium of multiple research labs, over 10 years to sequence the whole genomes of just a few individuals."
Edit: https://www.23andme.com/total-health
I guess they started providing whole exome sequencing, but I can't find information about what depth they're doing it at.
Of course the closer to a full sequence the better as any future research could be used by just reading existing data. But realistically just having data on few hundred most useful markers is enough.
I want to buy a machine, observe the whole process myself and then destroy/scrub the machine.
Last time I researched it the estimate was 5-6 digits, but I'm sure technology advancements have made it cheaper. What happened to that $1000 nanopore?
I have some acquaintances with lab experience who could run this, and could split the costs between friends and family. Everyone gets their own data, no copies are made, all samples are destroyed. We can resell the equipment after to recover some of the costs.
This is the best way to be sure about the data not leaking or getting sold to boost CEO bonus.