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A comment on Chemists tie a knot using only 54 atoms. Parent comment

Re:Chemists tie a knot using only 54 atoms by gilleain on Thursday January 25, 2024 @03:06PM (#39134476)
Thermal stability, as far as I know. So hyperthermophiles, presumably.

edit: hmmm. from this interesting review - https://www.sciencedirect.com/science/article/pii/S0959440X2... (open article) - it looks like some knots might increase mechanical stability and resitance to proteolysis

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Re:Chemists tie a knot using only 54 atoms by dekhn on Thursday January 25, 2024 @03:34PM (#39134854)
Oh, cool- they turned a not-truly-a-knot (open ends) protein into a truly knotted one (connected ends) and then unfolded it using urea and it stayed knotted. That's what you'd expect but it's also pretty cool.
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