Still - great for testing stuff out quickly.
But it's happening: I'm sure there are tens of thousands of HN readers who today keep their important data in hosted source code repositories, hosted accounting/invoicing packages, hosted CRM services, hosted e-mail services ... where both the software and the data do not necessarily live on their own machine. It hasn't happened as much in creative or engineering tools yet, but in my opinion, that's rapidly about to change as browsers become more and more capable platforms for powerful apps.
Furthermore, the line between "my software" and "cloud software" is being quickly blurred from both sides. From the existing desktop players, consider Adobe's Creative Suite becoming a subscription service / SaaS (http://news.ycombinator.com/item?id=3877191). And from the web apps side, consider that if we knew that people were willing to pay enough for it to be worth our time, we could package up CircuitLab to run as an offline app (already in the Chrome Web Store, but requires connection right now https://chrome.google.com/webstore/detail/haghanbgfkfpmepooh...).