Lethal Infection of Mice Caused by SARS-CoV-2-Related GX_P2V

Posted by segamegazord on Friday January 12, 2024 @07:26AM
from the biorxiv.org dept.

https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1

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Re:Lethal Infection of Mice Caused by SARS-CoV-2-Related GX_P2V by segamegazord on Friday January 12, 2024 @07:26AM (#38967238)

Abstract: SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.

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