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Re:Ubuntu Releases 12.04 LTS Precise Pangolin by mdesantis on Thursday April 26, 2012 @07:52AM (#3893401)
I use Unity with 2 monitors and it is pretty good; but I didn't try Gnome
Re:Ubuntu Releases 12.04 LTS Precise Pangolin by anthony_barker on Thursday April 26, 2012 @08:17AM (#3893490)
I run with Unity in one window and Windows xp in vmware in another 24" without problems. Gnome works too.

All you need to ensure is you have decent video card/drivers