It doesn’t literally explicitly contain regulations regarding air travel, because it did not exist in the 1700s.
If only the founders would have thought of that problem and included a method for which the constitution could be amended to grant additional powers to the federal government should the people and the states desire it...
But no it is easier to just invent new powers by continual reinterpretation of the documents than actually amending the document as required
However the actual wording is "to Regulate Commerce with foreign Nations, and among the several States", the original intent to was to give power to congress to regulate how commerce is conducted between the states, i.e prevent the coastal states from having tariffs against the internal states, and prevent the internal states from having export taxes on gains, etc etc etc
The original intent was not to allow the congress regulate individual commercial transactions by citizens that happen to cross state lines.