+1 to uWSGI and nginx. Now wsgi is built into nginx distribution, and uwsgi is gaining areputation for rock solid performance it's a nobrainer.

Likewise +1 to Nginx + uwsgi. In the various performance benchmarks* uwsgi beats gunicorn, and uwsgi comes bundled with Nginx now, so there's really no reason to bother with setting up gunicorn any more.

* http://www.peterbe.com/plog/fcgi-vs-gunicorn-vs-uwsgi http://nichol.as/benchmark-of-python-web-servers

Can you restart the uwsgi instance(s) without restarting nginx? That's a pretty significant benefit of gunicorn...

Yes, uwsgi instances run separately from nginx. The uwsgi nginx module simply speaks a binary protocol for reverse proxying rather than HTTP.

uwsgi comes bundles with Nginx? First I've heard of that. Very interesting.

Do you have any easy tutorials on getting Nginx + uwsgi set up?

The uwsgi upstream module has been bundled for a long time now.

Here is the doc from the uwsgi site: http://projects.unbit.it/uwsgi/wiki/RunOnNginx

I chose nginx and gevent after reading a blog post about py server performance. Anyone have any experience with these two?