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Re:Moderna's mRNA cancer vaccine works better than thought by mikewarot on Tuesday December 26, 2023 @08:39PM (#38778133)
I fail to see how anyone ever allowed the terms mRNA and Vaccine to be near each other. It's gene therapy, not a vaccine. I wish I hadn't been lied to before I, and my family, was injected with this stuff.

I guess I should have known better when the Pharma companies were pre-emptively granted immunity for any complications from this treatment. It roasts on the pyre any institutional trust the FDA and CDC had left.

As a result of all of this, the control group in this unplanned and reckless experiment is quite small. Its not outside of the realm of possibility to have a "Children of Men" situation in a decade or two because of this.

It may end up being that only the people who refused this have long and healthy lives.

Re:Moderna's mRNA cancer vaccine works better than thought by badsandwitch on Tuesday December 26, 2023 @08:50PM (#38778204)
mRNA can be used as indirect vaccine, by manipulating cellular factories to produce a foreign object that draws the attention of the immune system.

There is no known pathway of persistence in this mechanism, and there is good reason to believe such a mechanism cannot exist as it would be a highly versatile attack vector and viruses would have evolved to be much more virulent by using it. Retroviruses do complex work to infiltrate the DNA repository of a cell, if all it took is to drop some mRNA it would have been exploited and 'patched' a billion years ago.

Re:Moderna's mRNA cancer vaccine works better than thought by mikewarot on Wednesday December 27, 2023 @10:01AM (#38782587)
And if some of that mRNA happens to land in cells that don't readily get replaced, like heart muscle, what happens next?

>There is no known pathway of persistence in this mechanism

No known, and published in a paper, pathway. Engineering is about using things in practice we don't yet understand. They didn't know why suspension bridges kept falling down, so they just used a "safety factor" to decide how much to over-build a structure vs its theoretical capacity.

We have no idea what the long term consequences are of this gene treatment. It's not possible to have 10 year or more data on something just cooked up in the past 3 years.

Re:Moderna's mRNA cancer vaccine works better than thought by lawlessone on Wednesday December 27, 2023 @10:17AM (#38782786)
>We have no idea what the long term consequences are of this gene treatment.

It's mRNA for a start. So it isn't treating genes.

Re:Moderna's mRNA cancer vaccine works better than thought by mikewarot on Wednesday December 27, 2023 @03:44PM (#38786517)
>mRNA can be used as indirect vaccine, by manipulating cellular factories

That sounds like genetic manipulation to me.

Re:Moderna's mRNA cancer vaccine works better than thought by LorenPechtel on Wednesday December 27, 2023 @12:33AM (#38779395)
The reason they got immunity is that the percentage of claims about vaccines that are valid are minuscule. Juries don't do well when faced with an obviously harmed "victim" and a "bad guy" with deep pockets. They see the suffering victim and no evidence to prove yes or no on whether the "bad guy" inflicted the harm and tend to side with the victim.

The only way the vaccine industry can survive in such a legal climate is to get the claims reviewed by medical people rather than juries. Lawyers hate it because they can't woo the jury with the plight of the victim.

Society would work a lot better if more systems worked this way. Locally the lawyers utterly hated the system where to bring a malpractice case you had to go before a board of three lawyers and three doctors first. While you could then go to trial with less than 4 votes from that board your chances were minimal when the jury heard what the board said. Effectively that meant you had to convince one of three doctors your claim was sound--if you can't do that why do you think you have a case?