Mostly there isn't. It's about as useful as writing a program in brainfuck. https://en.wikipedia.org/wiki/Brainfuck# You do it precisely because it's hard, not because it's a good way to do it.

There are things you can do with shaders that might be useful for games. For example large simulations. But in generally, getting a game to work the way they work on ShaderToy is a fun puzzle but extremely inefficient and slow.