If you're in the fourth level of indentation, you might already have a readability problem.
"Might" being the key word. You might, if you are writing a simple script, but if you are writing some more complex code, class and method already take two levels, and that is your base line, I don't see how having two more levels is a readability problem.
I think having a soft and a hard limit makes more sense, if anything, I would make 80 characters the soft limit and perhaps 100 a hard limit, although I'd prefer them to be 100 and 120.