Vitamin B6 deficiency leads to social deficits and cognitive impairment

Re:Vitamin B6 deficiency leads to social deficits and cognit... by ty4smoking on Saturday December 09, 2023 @11:31AM (#38583240)

/? b6 b12 male smokers https://www.google.com/search?q=b6+b12+male+smokers

"Long-Term, High-Dose Vitamin B6/B12 Use Associated With Increased Lung Cancer Risk Among Men" (2023) https://cancer.osu.edu/news/long-term-high-dose-vitamin-b6-b... :

> Risk was further elevated in male smokers taking more than 20 milligrams of B6 or 55 micrograms of B12 a day for 10 years. Male smokers taking B6 at this dose were three times more likely to develop lung cancer. Male smokers taking B12 at such doses were approximately four times more likely to develop the disease compared to non-users.

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Re:Vitamin B6 deficiency leads to social deficits and cognit... by _xerces_ on Saturday December 09, 2023 @11:45AM (#38583350)

Those are very high doses of each. An average multivitamin has 1.8 mg of B6 (vs. 20 mg in the study) and 6 mcg of B12 (vs. 55 mcg in the study).

I am surprised anyone wants to take that much, but I guess the smokers were trying anything they could (short of actually quitting) to compensate for the effect their habit has on their health.

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Re:Vitamin B6 deficiency leads to social deficits and cognit... by mthoms on Saturday December 09, 2023 @11:58AM (#38583459)

Aren’t standalone B12 supplements typically measured in 3-4 digits (mcg)?

I’m currently taking 1000mcg daily but I’ve seen up to 2500 at the local pharmacy.

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Re:Vitamin B6 deficiency leads to social deficits and cognit... by geeB on Saturday December 09, 2023 @12:09PM (#38583541)

Absorption is poor sublingually and is limited by https://en.m.wikipedia.org/wiki/Intrinsic_factor so I wouldn’t be surprised if most of those doses just get destroyed in the stomach

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Re:Vitamin B6 deficiency leads to social deficits and cognit... by mthoms on Saturday December 09, 2023 @12:32PM (#38583770)

I have exactly that problem - malabsorption. The sublingual tablets have helped considerably.

I’m just trying to understand why the other commenter considers the dose mention as “high”. I’ve never heard that claimed before.

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Re:Vitamin B6 deficiency leads to social deficits and cognit... by _xerces_ on Saturday December 09, 2023 @03:36PM (#38585797)

I was referring to multivitamin levels which are typically ~100% RDA, so to get the levels the study considered harmful, you have to be intentionally taking large doses of B Vitamins which is easy not to do.

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Re:Vitamin B6 deficiency leads to social deficits and cognit... by ty4smoking on Monday December 11, 2023 @02:41PM (#38604468)

Some Caffeine Shots include very high doses of B6 and B12 vitamins.

## 2023-12: B6/B12 RDVs, RDV % Supplement Facts inconsistencies

5-Hour Energy nutrition facts: https://www.google.com/search?q=5+hour+energy+nutrition+fact... :

> B6: 40mg: 2000% RDV

> B12: 500mcg: 8333% RDV

5-Hour Energy Extra Strength:

> B6: 40mg: 2353%

> B12: 500mcg: 20833%

Summit Red Thunder Energy Shot nutrition facts: https://www.google.com/search?q=Summit+Red+Thunder+Energy+Sh...

> Kirkland Signature Extra Strength:

> B6: 40mg: 2533% RDV

> B12: 500mcg: 20833% RDV

...

Again,

/? b6 b12 male smokers https://www.google.com/search?q=b6+b12+male+smokers

"Long-Term, High-Dose Vitamin B6/B12 Use Associated With Increased Lung Cancer Risk Among Men" (2023) https://cancer.osu.edu/news/long-term-high-dose-vitamin-b6-b...

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