Disabling JS doesn’t magically make your site screen reader friendly. It’s entirely possible to create a shit layout that uses no JS and is just as horrible to use as a shit layout with JS. Likewise, adding JS doesn’t magically make your site non-screen reader friendly.

What actually makes a site screen reader friendly? Developers that actually write accessibility tests, tab through their site manually, open it with a blindfold and a screen reader to make sure they can navigate it, etc. This myth that no JS automagically enables accessibility needs to die.